I would suggest doing a few things, one of the most important, backups.
Backups of users uploaded data and data in the database are critcal..
You could also hook into a bug reporting service like Bugsnag or GetSentry GetSentry can also be hosted on your own server, see it here on Github
Other things could be setting up a load balancer so you're not reliant on one server and things like that, seperate application / database servers. Lots you can do.
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